Turning By-products Into Golden Peptides : The Latest Review And Interpretation Of Animal By-product Collagen Peptides + Actual Test By Hunan Jiayi
Jul 21, 2025
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Have you ever thought about it? When we are feasting heartily at the dining table, the bones, fish skins and internal organs that have been quietly discarded hide the unspoken tenderness of nature - they are the natural treasure trove of collagen and the health code that has been overlooked by time. Nowadays, one research after another rooted in laboratories is turning these animal by-products, which were once regarded as "waste", into precious gifts that nourish life.
Research Background: 20 million tons of by-products worldwide are being redefined in terms of value
According to the "Review of Animal By-Product Collagen and Its Derivative Peptides", in Europe alone, 20 million tons of animal by-products (bones, skins, tendons, etc.) are either underutilized or discarded each year. In China, the annual output of animal husbandry is 330 million tons, and the proportion of by-products is as high as 40%.
The global collagen market size was 4.7 billion US dollars in 2020 and is expected to reach 7 billion US dollars by 2027, with a compound annual growth rate of 5.9%. "Garbage" is turning into a trillion-yuan market.

Research Methods: Four major technical routes to fully utilize by-products
|
Steps |
Documentary-level scheme |
Jiayi has been upgraded and implemented |
|
Pre-treatment |
↑90%Pulsed electric field + vacuum degreasing, deodorization and fat removal rate ↑90% |
Low-temperature flash evaporation for efficient degreasing has significantly increased the extraction rate and degreasing rate |
|
Enzymatic hydrolysis |
Gastric/papaya/bromelain directed cleavage |
Double enzyme synergy + microwave assistance, yield ↑38% |
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Purification |
Ultrafiltration + gel chromatography, enrichment of 500-3000 Da oligopeptides |
Combined membrane filtration, with a proportion of 500-2000 Da of ≥92%, has a more concentrated molecular weight |
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Verification |
Full characterization of SDS-PAGE, FT-IR, LC-MS/MS |
Each batch is accompanied by a third-party test report, which can be checked by scanning the code |

Research samples: From cowhide to cod skin, covering the entire spectrum
Land: High-quality cowhide, cow bones, silkworm pupae, chicken cartilage, pigskin, sheepskin, etc
Ocean: Pure natural water tilapia/cod scales, skin, etc
Combination strategy: Bovine bone peptide + cod small molecule collagen peptide, achieving dual-channel nutrition of "bone + skin".
Key Data: One Article to Understand the "Chain of Efficacy Evidence
|
Function |
Experimental model |
Effective dose |
Highlights of the results |
|
Bone health |
Castrated rats |
800 mg/kg/ day ×90 days |
(Zhu et al., 2020)Density ↑18%, osteocalcin ↑25% (Zhu et al., 2020) |
|
Joint lubrication |
Patients with knee arthritis |
5 g per day for 6 months |
(Volpi et al., 2021)WOMAC pain score ↓32%, superior to glucosamine sulfate (Volpi et al., 2021) |
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Anti-aging of the skin |
UVB photoaged mice |
300 mg/kg/ day ×60 days |
Collagen fiber ↑34%, wrinkle area ↓41% (Zhang et al., 2017) |
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Cardiovascular |
Hypertensive rats |
100 mg/kg/ day ×30 days |
)Systolic blood pressure ↓21 mmHg, ACE inhibitory activity ↑46% (Zhuang et al., 2012) |
|
Immune enhancement |
Immunosuppressed mice |
50 mg/kg/ day ×30 days |
CD4+/CD8+ ratio ↑41%, spleen index ↑28% (Gao et al., 2019) |

Every year, tens of millions of tons of animal by-products are produced globally, and traditional processing methods often lead to a waste of resources. Hunan Jiayi Biotechnology has taken innovative enzymatic hydrolysis technology as a breakthrough point to convert by-products such as fish scales and beef bones into high-value-added collagen peptides, thus building a closed-loop industrial chain of "resources - technology - health".
Jiayi's Actual Test: Bringing Papers into Life
Process: Activate the activity with technology to double the absorption efficiency
Extracting collagen peptides tests the precise control of the "degree". Among traditional methods, enzymatic hydrolysis has become the preferred choice due to its mild reaction and ability to retain active ingredients. However, the introduction of innovative technologies has further enhanced efficiency - ultrasonic-assisted extraction can double the extraction rate and reduce the use of chemical reagents. Ultra-high pressure treatment can break the intermolecular bonds, making peptide chains more easily absorbed by the human body.
Based on this, Hunan Jiayi has independently created a "low-temperature enzymatic hydrolysis + membrane separation" process: First, food-grade protease is used to directionally cut collagen molecules at low temperatures, retaining active cores such as tripeptides (like Gly-Pro-Hyp); Then, small molecule peptides with a molecular weight of 1000-2000 daltons are screened out through ultrafiltration membranes, and the absorption rate can reach over 90%. This process avoids the damage to active ingredients caused by high temperatures and eliminates the digestive burden that may result from macromolecular peptides, allowing nutrients to truly "be consumed".
Scientific verification: Every efficacy is backed by data
The rigorous data from the laboratory is the "confidence" of Jiayi Collagen peptides:
• Golden amino acid ratio: Tests show that the proportion of glycine in Jiayi collagen peptides exceeds 30% (330+ per 1000 residues), and the total amount of proline and hydroxyproline is 140+. These two amino acids are the "skeleton" of the triple helix structure of collagen and can directly participate in the synthesis of human collagen .
The activity is solid: In vitro tests have shown that its inhibition rate of angiotensin-converting enzyme (ACE) is over 60%, which is helpful for regulating blood pressure. Antioxidant capacity (DPPH radical scavenging rate) reaches 85%, which can reduce cellular oxidative damage 2-133.
Safe and stress-free: Cytotoxicity tests show that even when the concentration reaches 5mg/mL, it has no impact on the survival rate of human fibroblasts. Pregnant women and those with sensitive skin can use it with confidence.
Actual measurement verification:
Population: Sedentary office workers aged 30 to 55, n=60
Take 16g of Jiayi Beef Tripeptide daily (8g for breakfast + 8g before going to bed) for 8 consecutive weeks
The result is:
Skin moisture meter: stratum corneum moisture ↑22%
Ultrasound bone mineral density: calcaneal T value ↑0.18
InBody: Body fat percentage ↓1.7%, muscle mass ↑0.8 kg
Sensation: The duration of morning stiffness decreased from 27 minutes to 14 minutes
The "Black Technology" three-piece set of Hunan Jiayi
Molecular weight lock freshness: 500-3000 Da oligopeptides, direct delivery from mouth to blood within 15 minutes.
Fishy smell: Patented enzymatic hydrolysis + low-temperature deodorization, only a faint milky aroma when brewed.
Additives: 0 sucrose, 0 fat, 0 preservatives. Suitable for pregnant women and people with lactose intolerance.
Breakfast: 8g peptide powder + oat milk to activate the joint lubrication mode
Afternoon tea: 8g peptide powder + Americano, caffeine + peptides work together to fight fatigue
BuffYoudaoplaceholder0 Before going to bed: 8g peptide powder + warm milk, a Buff for skin repair at night

When global scientific research turns by-products into a "functional peptide bank", Hunan Jiayi has already enabled you to bring laboratory achievements into your daily life - with just one sip, you are drinking a sustainable future of 20 million tons.

Multiple Benefits: Not Just for skin care, It's the "Nutritional Architect" for the whole body
The magic of collagen peptides lies in their ability to penetrate multiple systems of the body:
Skin system: After oral administration, tripeptides travel through the bloodstream directly to the dermis, promoting the synthesis of collagen and hyaluronic acid by fibroblasts. Clinical studies show that continuous intake for 8 weeks can increase skin water content by 20% and reduce wrinkle depth by 15%. The small molecule peptides of Hunan Jiayi are more easily absorbed by the skin. Combined with vitamin C ingredients, the "bouncy" effect is doubled
Bones and joints: It can activate the activity of osteoblasts, increase bone density, and at the same time inhibit the overactivity of osteoclasts. Studies on osteoporosis model mice have shown that collagen peptides can increase the number of trabeculae by 30%. Daily supplementation by sedentary people and middle-aged and elderly individuals can reduce joint wear and tear.
Cardiovascular and immune systems: The hydrophobic amino acids it contains can inhibit ACE activity and assist in regulating blood pressure. At the same time, it can enhance the activity of immune cells and make the body more resistant.
From the test tubes in the laboratory to the daily dining table, Hunan Jiayi Collagen Peptide has awakened the value of animal by-products with technology. It is not merely a nutritional supplement, but also a practice of "sustainable health" - not wasting nature's gifts, allowing everyone to easily obtain the dual care from the deep sea and technology.
Now, let this collagen peptide that embodies scientific wisdom become your "powerful assistant" in health management!
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